Expected 3V0-22.21 Exam Topics, as suggested by VMware :

• Module 1: Configure and manage High Availability options/ Set up a clustering solution for VMware vSphere® High Availability (HA)
• Module 2: Identify and implement vSphere® resource optimization opportunities/ Performance-tuning, Optimization, and Upgrades
• Module 3: Manage advanced virtual machine configurations (per VM EVC, latency sensitivity)/ Architectures and Technologies/ Products and Solutions/ Planning and Designing
• Module 4: Troubleshoot resource pool configuration issues (e.g. Limits/Sharing, hierarchy)/ Troubleshoot vSphere® configuration issues
• Module 5: Deploy and configure VMware vCenter Server® and VMware ESXi™/ Set up a cluster solution for VMware vSphere® Distributed Resource Scheduler™ (DRS)
• Module 6: Troubleshoot virtual machine reservations and VMware Admission Control/ Set up VMware vCenter Server® and single sign-on (SSO)
• Module 7: Configure and manage VMware vCenter Server® backup and restore options/ Set up log collection and VMware vCenter Server® backup
• Module 8: Configure and manage advanced cluster configurations (Quickstart, Admission Control)/ Configure the VMware Tools and vSphere® Client repository (productLocker)
• Module 9: Troubleshoot resource issues of the VMware vCenter Server®/ Manage and remediate clusters using vSphere® Lifecycle Manager™
• Module 10: Create and manage host profiles (e.g. edit and apply host profiles)/ Implement VMware vSphere® virtual machine encryption (VM encryption)
• Module 11: Configure CPU scheduler for security options/ Set up a cluster solution for VMware vSAN™
• Module 12: Deploy and manage VMware vSphere® Distributed Switch (VDS)/ Deploy and manage VMware vSphere® Standard Switch (vSS)